FITC标记的G蛋白信号转导调节因子12抗体
产品名称： FITC标记的G蛋白信号转导调节因子12抗体
英文名称： Anti-RGS12/FITC
产品编号： HZ--19853R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RGS12/FITC Conjugated antibody
FITC标记的G蛋白信号转导调节因子12抗体
| 英文名称 | Anti-RGS12/FITC |
| 中文名称 | FITC标记的G蛋白信号转导调节因子12抗体 |
| 别 名 | DKFZp761K1617; Regulator of G protein signalling 12. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 表观遗传学 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 156kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RGS12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008] Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. Subunit: Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent. Subcellular Location: Nuclear Tissue Specificity: Isoform 3 is brain specific. Similarity: Contains 1 GoLoco domain. Contains 1 PDZ (DHR) domain. Contains 1 PID domain. Contains 2 RBD (Ras-binding) domains. Contains 1 RGS domain. Database links: Entrez Gene: 6002 Human Entrez Gene: 71729 Mouse Entrez Gene: 54292 Rat Omim: 602512 Human SwissProt: O14924 Human SwissProt: Q8CGE9 Mouse SwissProt: O08774 Rat Unigene: 196208 Mouse Unigene: 9796 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
该基因编码G蛋白信号调节子（RGS）基因家族的一员。该编码蛋白可作为鸟苷三磷酸酶（GTPase）激活蛋白以及转录抑制因子发挥作用。这种蛋白可能在肿瘤发生中起作用。编码该基因的多个转录变体编码不同的亚型。其他替代剪接变异体已被描述，但它们的生物学性质尚未确定。[ RefSeq，JUL 2008 ]