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上海信裕生物科技有限公司
Prohibitin抗体

Prohibitin抗体

商家询价

产品名称： Prohibitin抗体

英文名称： ProhibitinAntibody

产品编号： XY10787-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 PROHIBITIN抗体Applications

In-house applications ELISA, IHC, WB, IF     Application not tested? Please see our Guarantee.
Published applications IHC, WB Publications 4 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human
Images
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  • 10787-1-AP;human liver cancer tissueImmunohistochemical of paraffin-embedded human liver cancer using 10787-1-AP(PHB antibody) at dilution of 1:50 (under 10x lens)
  • 10787-1-AP;human liver cancer tissueImmunohistochemical of paraffin-embedded human liver cancer using 10787-1-AP(PHB antibody) at dilution of 1:50 (under 40x lens)
  • 10787-1-AP;A431 cellsImmunofluorescent analysis of A431 cells using 10787-1-AP( Prohibitin Antibody) at dilution of 1:25 and FITC-Goat anti-Rabbit IgG
  • 10787-1-AP;HeLa cellsHeLa cells were subjected to SDS PAGE followed by western blot with 10787-1-AP(PHB antibody) at dilution of 1:1000
Positive WB detected in HeLa cells, A431 cells, human brain tissue, human liver tissue, Jurkat cells, mouse brain tissue, mouse heart tissue, mouse liver tissue, NIH/3T3 cells, Raji cells, rat brain tissue, rat heart tissue
Positive IHC detected in Human liver cancer tissue, human heart tissue
Positive IF detected in A431 cells
Recommended dilution WB : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:10-1:100
 PROHIBITIN抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen Prohibitin fusion protein ag1240 Full name Prohibitin
Calculated molecular
weight		 30 kDa Observed molecular 
weight		 30 kDa
GenBank accession 
number		 BC013401 Gene ID (NCBI) 5245
Gene symbol PHB Synonyms PHB, PHB1, prohibitin
Background PROHIBITIN抗体

Prohibitin, also known as PHB, a member of the Band-7 family of proteins, is widely distributed in bacteria, plants, yeast, protozoa and mammals and is important in cell proliferation, differentiation and apoptosis (PMID: 20840588 ). This protein localizes to the inner membrane of mitochondria, where it acts as a chaperone protein, and is also found in the nucleus, where it negatively regulates transcription (PMID: 18558096). Recent study confirmed that the expression and distribution of PHB, which is a nuclear matrix protein, affect the apoptosis of HaCaT cells and its co-localization with specific gene products connected with cell apoptosis (PMID: 24402549). PROHIBITIN抗体

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