FITC标记的酶动力蛋白1抗体
产品名称： FITC标记的酶动力蛋白1抗体
英文名称： Anti-Dynamin 1/FITC
产品编号： HZ-13038R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Dynamin 1/FITC Conjugated antibody
FITC标记的酶动力蛋白1抗体
| 英文名称 | Anti-Dynamin 1/FITC |
| 中文名称 | FITC标记的酶动力蛋白1抗体 |
| 别 名 | B dynamin; D100; DNM 1; DNM; DNM1; DYN1_HUMAN; Dynamin; Dynamin-1; Dynamin1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 转运蛋白 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 97kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Dynamin 1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Dynamin I is a GTPase enzyme required for the retrieval of synaptic vesicles after exocytosis and functions in endocytosis by stimulating assembly of invaginating synaptic vesicles (1). Dynamin I is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C (PKC) (2–5). The phosphorylation site in PKC-phosphorylated Dynamin I is a single site at Serine 795, which is located near a binding site for the SH3 domain of p85, the regulatory subunit of phosphatidylinositol 3-kinase (2–5). Dephosphorylation is required for synaptic vesicle retrieval, suggesting that phosphorylation affects the subcellular localization of Dynamin I (5). Mouse, rat and human Dynamin I are phosphorylated on serine residues, including Ser 778, by Cdk5, regulating PACSIN1 recruitment and enabling synaptic vesicle endocytosis. Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. Subunit: Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). Subcellular Location: Cytoplasm; Cytoplasm; cytoskeleton; Microtubule-associated. Similarity: Belongs to the dynamin family. Contains 1 GED domain. Contains 1 PH domain. Database links: Entrez Gene: 1759 Human Entrez Gene: 13429 Mouse Entrez Gene: 140694 Rat Omim: 602377 Human SwissProt: Q05193 Human SwissProt: P39053 Mouse SwissProt: P21575 Rat Unigene: 522413 Human Unigene: 44736 Mouse Unigene: 10354 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Dynamin I是一种GTP酶，在胞吐后恢复突触小泡，并通过刺激内陷突触小泡的组装在胞吞过程中起作用(1)。Dynamin I在神经末梢中通过蛋白激酶C(PKC)(2-5)在胞浆室和体外被磷酸化。PKC-磷酸化Dynamin I的磷酸化位点是丝氨酸795的一个位点，位于p85的SH3结构域的结合位点附近，p85是磷脂酰肌醇3-激酶(2-5)的调节亚基。突触囊泡提取需要脱磷酸化，表明磷酸化影响Dynamin I(5)的亚细胞定位。小鼠、大鼠和人Dynamin I被Cdk5磷酸化在丝氨酸残基上，包括Ser 778，调节PACSIN1募集和使突触囊泡内吞。