16号染色体开放阅读框41抗体
产品名称： 16号染色体开放阅读框41抗体
英文名称： CHTF18
产品编号： bs-13946R
产品价格： null
产品产地： 北京
品牌商标： BIOSS
更新时间： 2025-05-07T13:47:23
使用范围： WB=1:100-500,ELISA=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,
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CTF18 is a 975 amino acid protein encoded by the human gene CHTF18. CTF18 is a protein that is structurally related to the Rad24 and RFC (replication factor C) proteins. CTF18 is believed to form a novel RFC complex and functions redundantly with Rad24 in the DNA replication block checkpoint. The CTF18-RFC complex is a seven-subunit structure that consists of the four small subunits of RFC, together with CTF18, DCC1, and CTF8. This RFC complex is responsible for loading the replication clamp PCNA (Proliferating Cell Nuclear Antigen) onto DNA and functions in DNA replication and repair. Regulated unloading of PCNA during the progression and termination of DNA replication does not seem to be a function of the CTF18-RFC complex.