FITC标记的肿瘤抑制基因LPP2抗体
产品名称： FITC标记的肿瘤抑制基因LPP2抗体
英文名称： Anti-VANGL1/FITC
产品编号： HZ-8527R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-VANGL1/FITC Conjugated antibody
FITC标记的肿瘤抑制基因LPP2抗体
| 产品编号 | bs-8527R-FITC |
| 英文名称 | Anti-VANGL1/FITC |
| 中文名称 | FITC标记的肿瘤抑制基因LPP2抗体 |
| 别 名 | Loop tail protein 2 homolog; Loop-tail protein 2 homolog; LPP2; MGC5338; STB2; STBM2; Strabismus 2; Van Gogh like protein 1; Van Gogh-like protein 1; vang like 1 (van gogh, Drosophila); Vang like protein 1; Vang-like protein 1; VANG1_HUMAN; VANGL 1; LPP2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 信号转导 干细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 60 kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VANGL1/LPP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Vang family of proteins are integral membrane proteins that are homologues of the Drosophila tissue polarity gene strabismus. The gene encoding for Van Gogh-like protein 1 (Vangl1), also designated Strabismus 2 (STB2), localizes to human chromosome 1p11-p13.1. Van Gogh-like protein 2 (Vangl2), also designated Strabismus 1 (STB1), localizes to chromosome 1q22-q23. Vangl1 is expressed primarily in testis and ovary, but is also expressed in gastric and pancreatic cancer. Vangl proteins play a key developmental role in establishing planar cell polarity (PCP) and in regulating convergent extension (CE) movements during embryogenesis. Vangl1 and Vangl2 are both downregulated in several cancer cell lines and primary tumors. Subunit: Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein (Potential). Tissue Specificity: According to PubMed:11956595, ubiquitously expressed. According to PubMed:12011995, expressed specifically in testis and ovary. DISEASE: Defects in VANGL1 are a cause of neural tube defects (NTD) [MIM:182940]. NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis). Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM) [MIM:600145]. SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant. Similarity: Belongs to the Vang family. Database links: Entrez Gene: 81839 Human Entrez Gene: 229658 Mouse Entrez Gene: 690366 Rat Omim: 610132 Human SwissProt: Q8TAA9 Human SwissProt: Q80Z96 Mouse Unigene: 515130 Human Unigene: 118004 Mouse Unigene: 35269 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. LPP2是一种分子量为60kDa的多次跨膜蛋白，是Vang蛋白家族成员之一。VANGL1由524个氨基酸组成，其中包括4个跨膜结构域。VANGL1可能一种肿瘤抑制基因，该基因的突变会导致神经管缺失（neural tube defects ，NTD） |
Vang家族蛋白是果蝇组织极性基因斜视的同源膜蛋白。编码梵高样蛋白1（VangL1）的基因，也被命名为斜视2（STB2），定位于人类染色体1P11-p131。梵高样蛋白2（VangL2）也被命名为斜视1（STB1），定位于染色体1q22-q23。VANGL1主要在睾丸和卵巢中表达，但在胃和胰腺癌中也表达。Vangl蛋白在建立平面细胞极性（PCP）和调节胚胎发育过程中的收敛延伸（CE）运动中起着关键的发展作用。VangL1和VangL2在多种肿瘤细胞系和原发性肿瘤中均被下调。