FITC标记的双特异性磷酸酶抗体19抗体
产品名称： FITC标记的双特异性磷酸酶抗体19抗体
英文名称： Anti-DUSP19/FITC
产品编号： HZ-14454R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DUSP19/FITC Conjugated antibody
FITC标记的双特异性磷酸酶抗体19抗体
| 英文名称 | Anti-DUSP19/FITC |
| 中文名称 | FITC标记的双特异性磷酸酶抗体19抗体 |
| 别 名 | Dual specificity phosphatase 19; Dual specificity phosphatase TS DSP1; Dual specificity phosphatase TS-DSP1; Dual specificity protein phosphatase 19; DUS19_HUMAN; DUSP 17; DUSP 19; DUSP17; Dusp19; LMW DSP3; LMW-DSP3; LMWDSP 3; LMWDSP3; Low molecular weight dual specificity phosphatase 3; MGC138210; Protein phosphatase SKRP1; SAPK pathway regulating phosphatase 1; SAPK pathway-regulating phosphatase 1; SKRP 1; SKRP1; Stress activated protein kinase pathway regulating phosphatase 1; Stress-activated protein kinase pathway-regulating phosphatase 1; TS DSP1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 18, 24kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DUSP19 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] Function: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Tissue Specificity: Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain. Database links: Entrez Gene: 142679 Human Entrez Gene: 68082 Mouse Entrez Gene: 311151 Rat Omim: 611437 Human SwissProt: Q547H4 Human SwissProt: Q8WTR2 Human SwissProt: Q8K4T5 Mouse Unigene: 132237 Human Unigene: 306818 Mouse Unigene: 65563 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
双特异性磷酸酶（DUSP）是I型半胱氨酸基蛋白-酪氨酸磷酸酶超家族的一个大的异质亚群。DUSS的特征在于它们能够同时脱除酪氨酸和丝氨酸/苏氨酸残基。它们被认为是关键信号通路的主要调节剂。DUSP19包含一致的DUSP C-末端催化结构域的变化，最后一个丝氨酸残基被丙氨酸取代，并且缺少在DUSP的MKP(丝裂原活化蛋白激酶磷酸酶)类中发现的N-末端CH2结构域(见MIM 600714)(Patterson等人的摘要，2009[Pu]。[BMED 19228121 ]）[由OMIM提供，DEC 2009 ]