FITC标记的原钙粘蛋白γA4抗体
产品名称： FITC标记的原钙粘蛋白γA4抗体
英文名称： Anti-PCDHGA4/FITC
产品编号： HZ-11144R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCDHGA4/FITC Conjugated antibody
FITC标记的原钙粘蛋白γA4抗体
| 产品编号 | bs-11144R-FITC |
| 英文名称 | Anti-PCDHGA4/FITC |
| 中文名称 | FITC标记的原钙粘蛋白γA4抗体 |
| 别 名 | PCDHGA4; PCDHGA 4; PCDHGA-4; PCDH gamma A4; Protocadherin gamma A4; PCDG4_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 信号转导 细胞粘附分子 细胞骨架 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 98kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCDHGA4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin (PCDH) gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHGA4 (Protocadherin gamma-A4) is a 931 amino acid that is one of 22 proteins encoded by the protocadherin gamma cluster. The protocadherein gamma cluster consists of three subfamilies (A, B and C) and PCDHGA4 is a member of the gamma subfamily A. PCDHGA4 is a type I transmembrane receptor containing six cadherin motifs and is expressed in the central nervous system where it localizes to synapses. Members of the gamma cluster of protocadherins are essential for neuronal survival. There are two isoforms of PCDHGA4 that are produced as a result of alternative splicing events. Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Subcellular Location: Cell membrane; Single pass type I membrane protein Similarity: Contains 6 cadherin domains. Database links:
Entrez Gene: 56111 Human Entrez Gene: 93712 Mouse Entrez Gene: 252894 Rat UniProtKB/Swiss-Prot: Q9Y5G9.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
原粘蛋白是一大类钙黏蛋白样细胞粘附蛋白，参与脑内神经元连接的建立和维持。共有三个原粘蛋白（PCDH）基因簇，命名为α、β和γ，它们都含有多个排列整齐的基因。PCDHGA4（原粘蛋白GAMMA-A4）是由原粘蛋白γ簇编码的22种蛋白质中的931种氨基酸之一。原代Gamma簇由三个亚科（A、B和C）组成，PCDHGA4是γ亚家族的成员。PCDHGA4是I型跨膜受体，含有六个钙粘素基序，并在中枢神经系统中表达，其定位于突触。原核粘附素簇的成员对神经元存活至关重要。作为替代剪接事件的结果，产生了两种PCDHGA4的异构体。